Johnson & Johnson vaccine, leaflet: how it is done, side effects

Vaccino Johnson & Johnson, as well as for AstraZeneca, the Janssen product in Italy could undergo restrictions for the under 60s. This, in fact, when stated today by Undersecretary of Health Pierpaolo Sileri, who clarified during a radio broadcast. But how is the drug made? And what are the side effects? Here is the ‘leaflet’ published on the Aifa website. Read also What it is and what it is used for “COVID-19 Vaccine Janssen is a vaccine used to prevent COVID-19, a disease caused by the SARS-CoV-2 virus. COVID-19. Vaccine Janssen is given to adults aged 20 or older. 18. The vaccine causes the immune system (the body’s natural defenses) to produce antibodies and specialized white blood cells that act against the virus, offering protection against COVID-19. None of the components of this vaccine can cause COVID-19 “, reads the package leaflet. What it contains “The active ingredient – it continues – is a type 26 adenovirus, which encodes the spike glycoprotein of SARS-CoV-2 * (Ad26.COV2-S), no less than 8 92 log10 infectious units (U. Inf.) * In each 0.5 mL dose. * Produced in the PER.C6® TetR cell line and by recombinant DNA technology. This product contains genetically modified organisms (GMOs). The other components (excipients) are: – pack of 10 vials: 2-hydroxypropyl-β-cyclode strine (HBCD), citric acid monohydrate, ethanol, hydrochloric acid, polysorbate 80, sodium chloride, sodium hydroxide, trisodium citrate dihydrate, water for injections (see section 2 “COVID19 Vaccine Janssen contains sodium” and “COVID-19 Vaccine Janssen contains ethanol “). – Pack of 20 vials: 2-hydroxypropyl-β-cyclodextrin (HBCD), citric acid monohydrate, ethanol, hydrochloric acid, polysorbate 80, sodium chloride, sodium hydroxide, water for injections (see section 2″ COVID- 19 Vaccine Janssen contains sodium ”and“ COVID-19 Vaccine Janssen contains ethanol ”)”. Side Effects As with any vaccine, it still reads, “vaccination with COVID-19 Vaccine Janssen may not fully protect everyone who receives it. The length of the protection period is not known. “- Blood disorders: following vaccination with COVID-19 Vaccine Janssen, blood clots have been observed very rarely in association with low levels of platelets (cells that help blood clotting) in the blood. This condition includes severe cases of blood clots even in unusual sites such as the brain, liver, intestines and spleen, in some cases with the presence of bleeding. These cases have occurred in the first three weeks after vaccination and mainly in women under 60 years of age. This condition has also resulted in death. The leaflet instructs you to seek immediate medical attention if, after a few days of vaccination, severe or persistent headaches, seizures (convulsions), changes in mental status occur o blurred vision, if unusual bruises appear on the skin somewhere other than the vaccination site, very small round spots and located somewhere other than the vaccination site or if you experience shortness of breath, chest pain, leg pain, leg swelling or persistent abdominal pain. Also inform your healthcare professional (doctor, pharmacist or nurse) that you have recently received COVID-19 Vaccine Janssen.Like all vaccines, COVID-19 Vaccine Janssen can cause side effects, although not everybody gets them. Most of the side effects have occurred within 1-2 days of vaccination – Get medical attention immediately if you experience any of the following symptoms within 3 weeks of vaccination: severe or persistent headaches, blurred vision, changes in mental status o seizures (convulsions); wheezing, chest pain, leg swelling, leg pain, or persistent abdominal pain; unusual bruising on the skin or very small round spots located somewhere other than the vaccination site. Get urgent medical attention if you experience symptoms of a severe allergic reaction. These reactions may include a combination of some of the following symptoms: – feeling faint or light-headed – changes in heart beat – wheezing – wheezing – swelling of the lips, face or throat – hives or rash – nausea or vomiting – stomach pain The following side effects may also occur with this vaccine: Very common (may affect more than 1 in 10 people): headache, nausea, body aches, pain where the injection is given, sensation of extreme fatigue. Common (may affect up to 1 in 10 people): redness where the injection is given, swelling where the injection is given, chills, joint pain, fever, cough. Uncommon (may affect up to 1 in 100 people): rash, muscle weakness, pain in arms or legs, feeling of weakness, generally feeling unwell, sneezing, sore throat, back pain, tremor, excessive sweating. Rare (may affect up to 1 in 1000 people): allergic reaction, hives. Very rare (may affect up to 1 in 10,000 people): blood clots often in unusual sites (e.g. brain, intestine, liver, spleen) associated with low blood platelet levels Not known (frequency cannot be estimated on the basis of basis of available data) severe allergic reaction.