Moderna vaccine: what are vasculitis, these complications “deserving special expertise” according to the ANSM? – Free lunch

The National Agency for the Safety of Medicines evokes this Friday, April 15, cases of vasculitis after vaccination with the Moderna vaccine (Spikevax). Vaccine-related adverse effects that require special expertise. A potential signal to study considers the ANSM.

A new report published this Friday, April 15 by the ANSM (National Agency for the Safety of Medicines) reports several cases of adverse effects observed in data from March 25 to April 7, 2022. According to the agency, since the start of vaccination with the Spikevax vaccine (Moderna) 25,314 cases of adverse effects were analysed, of which “a large number of cases concern non-serious local delayed reactions” it is specified. But, following “an analysis of cases of vasculitis”, the monitoring committee considers that this may be “a potential signal with the Spikevax vaccine” which should lead to “particular expertise”. 26 cases If the number of reported cases, 26 confirmed out of the 62 analyzed, compared to the number of people vaccinated with Moderna is very low, this new study analyzes several autoimmune and inflammatory pathologies identified after an injection of the vaccine. But what are we talking about? “Vasculitides are a group of conditions having in common an inflammatory attack leading to fibrosis of the wall of arterial, venous and capillary vessels. The symptomatology depends on the type and number of vessels affected”, indicates the ANSM. The suffix “itis” indeed suggests cases of vascular inflammation, that is to say blood vessels. This inflammation can thus damage the tissues and organs directly supplied by these vessels. In total, it is estimated that there are about fifteen pathologies, quite rare, linked to vasculitis. They can affect both women and men of all ages. . The average time to onset is 9.3 days after vaccination. Of about sixty cases of vasculitis studied, 26 could be attributed to the vaccine. ansm Links to Kawasaki disease Covid-19 and Kawasaki disease in children are intertwined. This is what scientists remind about these potential adverse effects of the vaccine. To read also: Children, inflammatory syndromes and Covid-19: the alert from the Necker center in Paris “Vasculitides are recognized complications of SARS CoV2 disease (which include Kawasaki-type complications reported in particular in children). They would be linked to the inflammatory and immune response of the disease, of relative severity since intensive care is necessary for a third of patients, and the mortality is at 16% according to a summary study of the complications of SARS CoV2 “, can -we read. “Apart from Kawasaki, vasculitis of large and small vessels as well as cutaneous vasculitis are described, appearing within 2 weeks following Covid disease and can be serious, involving several organs”, further specifies the document. Given this study, the ANSM considers the threat of vasculitis after an injection of the Moderna vaccine to be serious: not very specific which persist in an inflammatory context”, estimates the agency which announces that it will continue the observations because it is there, “in particular on the attacks of small vessels”, of a “potential signal”. In total, since the start of vaccination with Moderna, more than 23,571,000 injections have been performed as of April 7, 2022.