AstraZeneca, second dose: ok Aifa to Pfizer and Moderna for under 60

Ok Aifa at the second dose with Pfizer and Moderna vaccines for the under 60s who received the first dose of astraZeneca vaccine. The second dose, with an mRna vaccine, will be given 8-12 weeks after the first dose. In Italy, after the last rare cases of thrombosis, AstraZeneca is reserved for the over 60s. Read also “The Technical Scientific Commission (CTS) of AIFA, in the meeting of 13 June 2021, expressed its opinion on how to use the mixed vaccination schedule in subjects under 60 years of age who received a first dose of Vaxzevria vaccine, also in consideration of the changed epidemiological scenario of reduced viral circulation “, reads the note.” Based on clinical studies published in recent weeks, the CTS decided to approve the vaccine mix (first dose with Vaxzevria and second dose with Comirnaty or, by analogy, with the Moderna vaccine), in the face of a significant enhancement of the antibody response and a good reactogenicity profile “, continues the commission. Therefore, “in consideration of the evidence that has just become available, of the current absence of specific indications in the Summary of Product Characteristics (SmPC) of the drugs in question and the need to allow the vaccination campaign to run smoothly “, Aifa expressed a favorable opinion” for the inclusion in the list of drugs pursuant to law 648/1996 of Comirnaty and Vaccino COVID-19 Moderna as a second dose to complete a mixed vaccination course, in subjects under the age of 60 who have already received a first dose of Vaxzevria vaccine “. The Commission “considered that the second mRNA vaccine administration could take place 8-12 weeks after the administration of Vaxzevria”.