• Mon. Jan 24th, 2022

Tumors, Car-T cell therapy: first 3 children successfully treated

Byeditorial

Jun 8, 2021

The first three children undergoing therapy with freshly obtained Car-T cells in Italy were successfully treated, thanks to an innovative automated production. The three young patients had a particular type of leukemia – acute lymphoid leukemia with B-cell precursors (Lla-Bcp) – which proved refractory to all conventional therapies. This was announced by the Ministry of Health in a note. As early as two weeks after the infusion, complete remission of the disease was ascertained in the three children. For them, conventional treatments had not produced the expected results. One of the three children had even failed an allogeneic hematopoietic stem cell transplant procedure, the ministry recalls. The three children were treated with genetically modified cells produced by the pharmaceutical workshop of the Bambino Gesù pediatric hospital in Rome through an automated system, developed as part of the Car-T Italia project. The project was promoted by the Parliament, which allocated 10 million euros to the Ministry of Health, to make this new therapeutic approach available throughout the country. For all three children, time has now matured to assess response to treatment and complete remission of the disease has been documented. The three small patients were included in the new experimental treatment protocol and treated with cells that were genetically modified to express a receptor called Car (Chimeric Antigen Receptor) directed towards the tumor target Cd19. “The automated system allows to produce several batches of Car-T cells simultaneously within the same environment in just two weeks, to reduce the staff required for manufacturing, to contain the risk of product contamination and to generate highly standardized procedures and, therefore, reproducible, significantly limiting production costs. Thanks to the characteristics of this approach, the therapy is made more accessible even for patients suffering from the most aggressive forms of the disease “, underline the experts. In the three cases it was possible to obtain a number of Car-T cells much higher than the dose necessary for the first phase of the treatment, allowing to freeze part of the cells produced, for possible future consolidation treatments. A spare capacity, which demonstrates the feasibility and efficiency of the production process – continues the Ministry of Health – In the three patients the infusion of the fresh product was well tolerated, with only fever, due to the release of inflammatory molecules (cytokines) from Car-T cells. The success on the three children “is an extremely promising preliminary result – it is emphasized – confirming how the new Car-T cell platform demonstrates a remarkable efficacy against refractory forms of Lla-Bcp, despite having been tested only at the dose level. lower, as foreseen by the trial phase I. The study will continue with the evaluation of two other dose levels and with the activation of phase II, in which the recommended dose will be used, identified in phase I “. on Car-T cells for malignant haematological diseases and solid tumors is conducted by the Irccs of the Alliance Against Cancer Network (Acc) on the basis of the agenda of the Chamber of Deputies of 30 December 2019, which outlined the implementation path for the development of these new therapies. The project is aimed at better understanding the mechanisms that regulate the efficacy or possible toxicity associated with the use of this innovative form of immunotherapy, to develop this therapeutic approach also for patients with solid neoplasms and to identify the productive processes capable of to make these therapies available to as many patients as possible. “Research on advanced therapies is of strategic value, in order to offer citizens the best possible treatment options. The results of this important project are a significant step forward in this direction and confirm that it is essential to continue investing in research “underlines the Minister of Health, Roberto Speranza, commenting on the results obtained from the Car-T Italia project.” As project coordinator and head of the Bambino Gesù hospital group, I am particularly happy for this result – comments Franco Locatelli, director of the Department of Oncohematology of the Child Jesus and President of the Higher Health Council – The decision of the Italian Parliament, to which all of us researchers belonging to the Project are extraordinarily grateful, to invest in such an innovative field thus finds a concrete therapeutic realization that will certainly be followed by others applications in patients suffering from different oncological pathologies “.

One thought on “Tumors, Car-T cell therapy: first 3 children successfully treated”
  1. editorial says:

    https://pagalguy.com/discussions/hack-spike-strips-hack-mod-apk-cheats-generator-ios-android-110997204141064
    https://pagalguy.com/discussions/update-gramywtopl-hack-mod-apk-cheats-generator-ios-android-110935528582677
    https://peatix.com/user/8566388
    https://pagalguy.com/discussions/hack-elevens-up-hack-mod-apk-cheats-generator-ios-android-99004041517406
    https://pagalguy.com/discussions/hack-ice-cream-robot-van-transform-hack-mod-apk-cheats-generator-ios-android-99010209530344
    https://pagalguy.com/discussions/hack-lasten-rekat-palapelit-hack-mod-apk-cheats-generator-ios-android-110845016010916
    https://peatix.com/user/8574526
    https://peatix.com/user/8573389
    https://pagalguy.com/discussions/update-fuga-da-laville-2-hack-mod-apk-cheats-generator-ios-android-110971816293353
    https://peatix.com/user/8534969
    https://peatix.com/user/8559763
    https://peatix.com/user/8572513
    https://peatix.com/user/8564428
    https://pagalguy.com/discussions/new-monster-flicks-spa-smink-hack-mod-apk-cheats-generator-ios-android-110746382240770
    https://pagalguy.com/discussions/new-hack-moto-3d-spiele-kostenlos-motorrad-fahren-hack-mod-apk-cheats-generator-ios-android-110978347482436
    https://peatix.com/user/8568294
    https://pagalguy.com/discussions/new-hack-us-taxi-simulator-hack-mod-apk-cheats-generator-ios-android-110869224123190
    https://peatix.com/user/8562126
    https://peatix.com/user/8537341
    https://pagalguy.com/discussions/update-chessimo-20-hack-mod-apk-cheats-generator-ios-android-110975636095714
    https://peatix.com/user/8564176
    https://peatix.com/user/8568474
    https://peatix.com/user/8557521
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110826561995929
    https://pagalguy.com/discussions/new-juice-fruity-splash-hack-mod-apk-cheats-generator-ios-android-110977315088466
    https://peatix.com/user/8546142
    https://peatix.com/user/8565144
    https://peatix.com/user/8538503
    https://peatix.com/user/8561261
    https://peatix.com/user/8575785
    https://peatix.com/user/8562466
    https://pagalguy.com/discussions/hack-word-hero-search-puzzle-hack-mod-apk-cheats-generator-ios-android-110972118748195
    https://peatix.com/user/8572386
    https://pagalguy.com/discussions/hack-nun-neighbor-escape-hack-mod-apk-cheats-generator-ios-android-99016183065350
    https://pagalguy.com/discussions/new-hack-pixel-craft-survive-hack-mod-apk-cheats-generator-ios-android-110842467336792
    https://pagalguy.com/discussions/new-hack-ola-around-the-world-hack-mod-apk-cheats-generator-ios-android-110955678350932
    https://peatix.com/user/8575548
    https://peatix.com/user/8564137
    https://peatix.com/user/8554362
    https://peatix.com/user/8552914
    https://pagalguy.com/discussions/new-hack-mod-apk-cheats-generator-ios-android-110995763677904
    https://peatix.com/user/8536902
    https://pagalguy.com/discussions/new-18-wheel-extreme-truck-driving-hack-mod-apk-cheats-generator-ios-android-110930966972380
    https://pagalguy.com/discussions/new-2-hack-mod-apk-cheats-generator-ios-android-99013962239889
    https://pagalguy.com/discussions/hack-steampunk-syndicate-hack-mod-apk-cheats-generator-ios-android-110809948965387
    https://pagalguy.com/discussions/new-hack-mod-apk-cheats-generator-ios-android-110966412798628
    https://peatix.com/user/8571782
    https://pagalguy.com/discussions/update-phone-dice-hack-mod-apk-cheats-generator-ios-android-96079547140607
    https://pagalguy.com/discussions/update-solitario-all-peaks-hack-mod-apk-cheats-generator-ios-android-110982818685317
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110947654308582
    https://pagalguy.com/discussions/new-halloween-makeover-salon-kids-makeup-games-hack-mod-apk-cheats-generator-ios-android-110991927816900
    https://pagalguy.com/discussions/hack-boat-drift-sling-race-hack-mod-apk-cheats-generator-ios-android-110997599792248
    https://pagalguy.com/discussions/new-hack-dreeps-alarm-playing-game-hack-mod-apk-cheats-generator-ios-android-110998019966154
    https://pagalguy.com/discussions/new-hack-hack-mod-apk-cheats-generator-ios-android-110968602810592
    https://pagalguy.com/discussions/new-criancas-sujas-makeover-hack-mod-apk-cheats-generator-ios-android-110869812597679
    https://pagalguy.com/discussions/hack-multiplicacion-y-division-hack-mod-apk-cheats-generator-ios-android-110964909045101
    https://peatix.com/user/8575656
    https://pagalguy.com/discussions/hack-phrazin-hack-mod-apk-cheats-generator-ios-android-110986828681534
    https://pagalguy.com/discussions/new-time-and-crime-hack-mod-apk-cheats-generator-ios-android-99030605035770
    https://pagalguy.com/discussions/new-hack-mad-maths-hack-mod-apk-cheats-generator-ios-android-110996307416910
    https://pagalguy.com/discussions/hack-big-home-hidden-objects-game-hack-mod-apk-cheats-generator-ios-android-110981693903973
    https://pagalguy.com/discussions/update-cat-spa-hack-mod-apk-cheats-generator-ios-android-110864979364918
    https://pagalguy.com/discussions/hack-room-escape-hack-mod-apk-cheats-generator-ios-android-109264190965435
    https://pagalguy.com/discussions/new-hack-uno-color-card-game-hack-mod-apk-cheats-generator-ios-android-110954367342985
    https://peatix.com/user/8573283
    https://peatix.com/user/8571218
    https://peatix.com/user/8560217
    https://peatix.com/user/8571897
    https://peatix.com/user/8550112
    https://pagalguy.com/discussions/new-ertugrul-gazi-2-hack-mod-apk-cheats-generator-ios-android-96079966428914
    https://peatix.com/user/8570091
    https://peatix.com/user/8570768
    https://peatix.com/user/8554990
    https://peatix.com/user/8569846
    https://pagalguy.com/discussions/new-hack-mahjong-puzzle-deluxe-3d-pro-classic-card-game-hack-mod-apk-cheats-generator-ios-android-99035740652916
    https://pagalguy.com/discussions/hack-beatstar-hack-mod-apk-cheats-generator-ios-android-110983942792857
    https://peatix.com/user/8572050
    https://pagalguy.com/discussions/new-hack-100t-earth-defender-s-hack-mod-apk-cheats-generator-ios-android-110912049148880
    https://pagalguy.com/discussions/update-doodle-creaturestm-alchemy-hack-mod-apk-cheats-generator-ios-android-110992006950621
    https://pagalguy.com/discussions/update-fun-race-color-hole-party-3d-hack-mod-apk-cheats-generator-ios-android-110961799490255
    https://pagalguy.com/discussions/new-hack-klondike-hack-mod-apk-cheats-generator-ios-android-96052654681774
    https://pagalguy.com/discussions/new-hack-hummer-coche-transporte-avion-hack-mod-apk-cheats-generator-ios-android-109282609590359
    https://peatix.com/user/8564649
    https://peatix.com/user/8573799
    https://peatix.com/user/8563220
    https://pagalguy.com/discussions/update-dentist-office-pets-vet-doctor-hack-mod-apk-cheats-generator-ios-android-110989655228414
    https://pagalguy.com/discussions/hack-juegos-rompecabezas-para-ninos-hack-mod-apk-cheats-generator-ios-android-110742687158268
    https://pagalguy.com/discussions/new-smart-educational-games-hack-mod-apk-cheats-generator-ios-android-110978690096521
    https://pagalguy.com/discussions/hack-solitaire-tripeaks-rose-garden-hack-mod-apk-cheats-generator-ios-android-110906990418856
    https://pagalguy.com/discussions/hack-super-mom-groom-the-room-game-hack-mod-apk-cheats-generator-ios-android-110970623674115
    https://peatix.com/user/8563168
    https://peatix.com/user/8568863
    https://peatix.com/user/8574327
    https://pagalguy.com/discussions/new-hack-the-bible-trivia-challenge-hack-mod-apk-cheats-generator-ios-android-110963781598318
    https://pagalguy.com/discussions/hack-stunt-game-extreme-car-racing-rival-simulator-3d-hack-mod-apk-cheats-generator-ios-android-110912754617503
    https://pagalguy.com/discussions/new-hack-word-owls-wordsearch-halloween-hack-mod-apk-cheats-generator-ios-android-110981921012884
    https://pagalguy.com/discussions/new-brnespil-dyrene-fra-bondegarden-fuld-udgave-hack-mod-apk-cheats-generator-ios-android-110986301881553
    https://pagalguy.com/discussions/update-hack-mod-apk-cheats-generator-ios-android-110931055341544
    https://pagalguy.com/discussions/new-hack-cover-fire-shooting-games-3d-hack-mod-apk-cheats-generator-ios-android-96045922765519
    https://pagalguy.com/discussions/hack-elephant-survival-simulator-hack-mod-apk-cheats-generator-ios-android-110928507101773
    https://pagalguy.com/discussions/hack-extreme-balancer-2-hack-mod-apk-cheats-generator-ios-android-110995220970060
    https://peatix.com/user/8544692
    https://peatix.com/user/8570950
    https://pagalguy.com/discussions/new-true-horror-hack-mod-apk-cheats-generator-ios-android-110733907740245
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110927883330020
    https://pagalguy.com/discussions/update-marble-clash-hack-mod-apk-cheats-generator-ios-android-109278976265557
    https://pagalguy.com/discussions/new-fall-waterpark-hack-mod-apk-cheats-generator-ios-android-110997733531799
    https://pagalguy.com/discussions/hack-island-tribe-2-hack-mod-apk-cheats-generator-ios-android-110839228049361
    https://pagalguy.com/discussions/update-slide-to-freedom-hack-mod-apk-cheats-generator-ios-android-110972386286682
    https://pagalguy.com/discussions/new-hack-mod-apk-cheats-generator-ios-android-110830689014926
    https://peatix.com/user/8568933
    https://peatix.com/user/8563891
    https://pagalguy.com/discussions/update-treasure-miner-2d-gem-mine-hack-mod-apk-cheats-generator-ios-android-110937989313346
    https://peatix.com/user/8566264
    https://peatix.com/user/8569196
    https://pagalguy.com/discussions/update-extreme-smash-cockroach-hack-mod-apk-cheats-generator-ios-android-110858957533393
    https://pagalguy.com/discussions/hack-solitaire-hack-mod-apk-cheats-generator-ios-android-109268362369407
    https://pagalguy.com/discussions/new-hack-baby-shark-8bit-hack-mod-apk-cheats-generator-ios-android-110995862581990
    https://peatix.com/user/8557138
    https://peatix.com/user/8567528
    https://peatix.com/user/8564005
    https://pagalguy.com/discussions/update-land-of-livia-an-epic-fantasy-hack-mod-apk-cheats-generator-ios-android-110998071560403
    https://peatix.com/user/8571451
    https://pagalguy.com/discussions/new-conducao-de-comboios-de-selva-hack-mod-apk-cheats-generator-ios-android-96305721553013
    https://peatix.com/user/8568410
    https://pagalguy.com/discussions/new-hack-fangen-sie-die-goldmunzen-geld-simulation-spiel-20-hack-mod-apk-cheats-generator-ios-android-110982179695824
    https://pagalguy.com/discussions/update-hack-mod-apk-cheats-generator-ios-android-110992936152022
    https://pagalguy.com/discussions/new-crazy-skater-kid-hack-mod-apk-cheats-generator-ios-android-110984012718759
    https://peatix.com/user/8568280
    https://peatix.com/user/8570586
    https://pagalguy.com/discussions/update-shopmath-juegos-de-tiendas-para-ninos-y-ninas-p-hack-mod-apk-cheats-generator-ios-android-110835656929505
    https://peatix.com/user/8528656
    https://pagalguy.com/discussions/new-hack-pc-creator-pro-hack-mod-apk-cheats-generator-ios-android-110977635651742
    https://peatix.com/user/8575308
    https://peatix.com/user/8575577
    https://peatix.com/user/8558599
    https://pagalguy.com/discussions/new-hack-ball-smasher-tm-hack-mod-apk-cheats-generator-ios-android-110765423853968
    https://peatix.com/user/8575572
    https://peatix.com/user/8532958
    https://peatix.com/user/8552498
    https://pagalguy.com/discussions/hack-drone-strike-hack-mod-apk-cheats-generator-ios-android-109299553966899
    https://pagalguy.com/discussions/new-cute-cookie-maker-hack-mod-apk-cheats-generator-ios-android-110983406175775
    https://peatix.com/user/8573987
    https://peatix.com/user/8538829
    https://pagalguy.com/discussions/update-dino-pet-factory-hack-mod-apk-cheats-generator-ios-android-109294467066344
    https://pagalguy.com/discussions/update-flight-chess-hack-mod-apk-cheats-generator-ios-android-110847722318438
    https://pagalguy.com/discussions/new-hack-fleece-lightning-hack-mod-apk-cheats-generator-ios-android-110854881817195
    https://pagalguy.com/discussions/new-evolution-x-horizon-racer-turbo-extreme-racing-3d-free-game-hack-mod-apk-cheats-generator-ios-android-110929906852647
    https://peatix.com/user/8562276
    https://pagalguy.com/discussions/new-super-arsenal-hack-mod-apk-cheats-generator-ios-android-110852781405456
    https://pagalguy.com/discussions/new-hack-hack-mod-apk-cheats-generator-ios-android-110979326813726
    https://pagalguy.com/discussions/update-christmas-swap-3-hack-mod-apk-cheats-generator-ios-android-99017648565580
    https://pagalguy.com/discussions/update-flick-hurling-hack-mod-apk-cheats-generator-ios-android-99038692985351
    https://pagalguy.com/discussions/new-farkle-10000-hack-mod-apk-cheats-generator-ios-android-110846341756274
    https://pagalguy.com/discussions/new-hack-drone-mania-hack-mod-apk-cheats-generator-ios-android-110974891182672
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110731030931029
    https://peatix.com/user/8574744
    https://peatix.com/user/8574017
    https://pagalguy.com/discussions/hack-tennis-pro-tennis-clash-games-hack-mod-apk-cheats-generator-ios-android-110979736295024
    https://peatix.com/user/8550939
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110855384453820
    https://peatix.com/user/8570008
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110862083519121
    https://peatix.com/user/8561848
    https://peatix.com/user/8568412
    https://pagalguy.com/discussions/hack-figurine-di-calcio-quiz-hack-mod-apk-cheats-generator-ios-android-110952154006587
    https://pagalguy.com/discussions/new-hack-mod-apk-cheats-generator-ios-android-99031682514646
    https://pagalguy.com/discussions/update-blocks-numbers-puzzle-hack-mod-apk-cheats-generator-ios-android-110971888492535
    https://pagalguy.com/discussions/new-wit-mind-fighters-hack-mod-apk-cheats-generator-ios-android-109305325889932
    https://peatix.com/user/8559438
    https://pagalguy.com/discussions/new-hack-combat-elite-army-2017-hack-mod-apk-cheats-generator-ios-android-110931620083750
    https://pagalguy.com/discussions/hack-monstro-aventura-run-ponta-2d-jogo-gratis-hack-mod-apk-cheats-generator-ios-android-110788703266917
    https://peatix.com/user/8572813
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110984836374390
    https://peatix.com/user/8570079
    https://pagalguy.com/discussions/hack-hercules-run-hack-mod-apk-cheats-generator-ios-android-110960691400181
    https://peatix.com/user/8551206
    https://pagalguy.com/discussions/new-hook-hero-hack-mod-apk-cheats-generator-ios-android-110959780889943
    https://pagalguy.com/discussions/new-quizworks-hack-mod-apk-cheats-generator-ios-android-110781712629439
    https://peatix.com/user/8556645
    https://peatix.com/user/8548798
    https://pagalguy.com/discussions/update-paises-de-oceania-hack-mod-apk-cheats-generator-ios-android-99020436682048
    https://pagalguy.com/discussions/update-salon-de-belleza-y-arte-de-una-hack-mod-apk-cheats-generator-ios-android-110989141855094
    https://pagalguy.com/discussions/new-spades-hack-mod-apk-cheats-generator-ios-android-96078015352394
    https://peatix.com/user/8573368
    https://peatix.com/user/8571019
    https://pagalguy.com/discussions/new-mousehunt-world-hack-mod-apk-cheats-generator-ios-android-110969103067537
    https://peatix.com/user/8568216
    https://pagalguy.com/discussions/new-mtg-events-hack-mod-apk-cheats-generator-ios-android-99016637733818
    https://peatix.com/user/8563623
    https://peatix.com/user/8562672
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110946680135291
    https://peatix.com/user/8574088
    https://peatix.com/user/8562359
    https://peatix.com/user/8537098
    https://pagalguy.com/discussions/new-hack-game-quiz-can-you-guess-all-the-video-games-hack-mod-apk-cheats-generator-ios-android-110830019996651
    https://pagalguy.com/discussions/new-wizards-quiz-hack-mod-apk-cheats-generator-ios-android-110996731948968
    https://pagalguy.com/discussions/new-write-formula-hack-mod-apk-cheats-generator-ios-android-110944894197215
    https://peatix.com/user/8566376
    https://peatix.com/user/8575070
    https://peatix.com/user/8573132
    https://peatix.com/user/8569662
    https://peatix.com/user/8575391
    https://peatix.com/user/8575569
    https://pagalguy.com/discussions/hack-let-me-go-hack-mod-apk-cheats-generator-ios-android-110856697663349
    https://peatix.com/user/8562783
    https://peatix.com/user/8560878
    https://pagalguy.com/discussions/new-hack-radar-game-hack-mod-apk-cheats-generator-ios-android-110938889794476
    https://pagalguy.com/discussions/hack-csc-exams-philippines-hack-mod-apk-cheats-generator-ios-android-110983228269030
    https://pagalguy.com/discussions/new-hack-paciencia-spider-hack-mod-apk-cheats-generator-ios-android-110983798048377
    https://pagalguy.com/discussions/hack-cribbage-pro-contests-hack-mod-apk-cheats-generator-ios-android-110922837826024
    https://peatix.com/user/8570341
    https://pagalguy.com/discussions/new-hack-hack-mod-apk-cheats-generator-ios-android-110996768386991
    https://pagalguy.com/discussions/new-hack-temple-rescue-hack-mod-apk-cheats-generator-ios-android-110909924187574
    https://pagalguy.com/discussions/new-248-connect-dots-and-numbers-hack-mod-apk-cheats-generator-ios-android-110743796844836
    https://peatix.com/user/8548484
    https://pagalguy.com/discussions/hack-reto-de-logica-hack-mod-apk-cheats-generator-ios-android-110804932842915
    https://peatix.com/user/8562560
    https://peatix.com/user/8544398
    https://pagalguy.com/discussions/new-hack-war-poker-table-game-hack-mod-apk-cheats-generator-ios-android-110979101355505
    https://pagalguy.com/discussions/new-hack-talisman-origins-hack-mod-apk-cheats-generator-ios-android-110968646375659
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-110872027937093
    https://peatix.com/user/8571467
    https://pagalguy.com/discussions/new-hack-high-school-fighter-best-action-fighting-game-hack-mod-apk-cheats-generator-ios-android-110969820802620
    https://peatix.com/user/8558003
    https://peatix.com/user/8558690
    https://pagalguy.com/discussions/hack-real-football-worldcup-futbol-hack-mod-apk-cheats-generator-ios-android-96082419274062
    https://pagalguy.com/discussions/new-hack-sudoku-freepuzzle-hack-mod-apk-cheats-generator-ios-android-110953724169501
    https://pagalguy.com/discussions/new-hack-contrei-live-hack-mod-apk-cheats-generator-ios-android-110933485121830
    https://peatix.com/user/8575592
    https://pagalguy.com/discussions/update-human-devolution-hack-mod-apk-cheats-generator-ios-android-110998068345042
    https://pagalguy.com/discussions/hack-hack-mod-apk-cheats-generator-ios-android-99005044674319
    https://peatix.com/user/8575546
    https://pagalguy.com/discussions/new-hack-battle-simulator-counter-stick-hack-mod-apk-cheats-generator-ios-android-110997690489996
    https://pagalguy.com/discussions/new-jungle-kings-hack-mod-apk-cheats-generator-ios-android-110866349005086
    https://peatix.com/user/8558867
    https://pagalguy.com/discussions/new-hack-mod-apk-cheats-generator-ios-android-110945898792513
    https://pagalguy.com/discussions/new-ninja-boy-adventures-bomberman-edition-hack-mod-apk-cheats-generator-ios-android-110831652253054
    https://peatix.com/user/8553933
    https://pagalguy.com/discussions/new-mad-teacher-hack-mod-apk-cheats-generator-ios-android-110976982233094
    https://peatix.com/user/8573751
    https://peatix.com/user/8558043
    https://pagalguy.com/discussions/new-tetro-legend-block-puzzle-hack-mod-apk-cheats-generator-ios-android-96082025457716
    https://pagalguy.com/discussions/new-hack-word-turds-palabras-en-espanol-hack-mod-apk-cheats-generator-ios-android-110744488864281
    https://pagalguy.com/discussions/hack-sudoku-solver-supreme-free-hack-mod-apk-cheats-generator-ios-android-110998636366156
    https://pagalguy.com/discussions/new-hack-hack-mod-apk-cheats-generator-ios-android-99015303760313
    https://peatix.com/user/8546082
    https://peatix.com/user/8575870
    https://peatix.com/user/8564237
    https://pagalguy.com/discussions/new-fishing-time-hack-mod-apk-cheats-generator-ios-android-110732591253701

Comments are closed.