Why haven’t the side effects of vaccines been studied in animals? – International Network

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through Patrice Gibertie.

Can we conceive of a vaccination, which is in fact compulsory, if all the precautions have not been taken before authorization. In 2020 Shibo Jiang (professor of virology at the School of Basic Medical Sciences, Fudan University, Shanghai, China, and the New York Blood Center, New York, USA) was warning : “ My concern is that this could mean that a vaccine is given before its efficacy and safety has been fully evaluated in animal models or clinical trials. “.

Work with the SARS virus shows disturbing immune responses have been observed in ferrets and monkeys, but not in mice. Why were the experiments not carried out on several species for the Pfizer and the others? 42 unfortunate macaques were indeed used but in no case to check the side effects of vaccines. It was simply a question of verifying the effectiveness of the vaccine against the virus.

No study on the effects of the spike protein after injection, no answer to the question posed by the safety of the active spike protein. It should be remembered that this is not an inactivated virus but an active principle which should quickly disappear from the body after the injection and the appearance of the antibodies.

What if she had time to wreak havoc? What if it airs for much longer than expected? What if it triggered a form of Covid?

WE GET A BETTER UNDERSTANDING WHY THE MOST DOSED OF VACCINES, MODERNA IS BANNED FOR YOUNG PEOPLE IN THE SCANDINAVIAN COUNTRIES.

Recent experiments with mice may be of concern

THE LATEST STUDIES PROVIDE PROOF that the precautionary principle has been forgotten.

A series of very recent studies show that the famous S protein Spike alone produces considerable damage. It should be remembered that vaccines inoculate the RNA of the said S protein so that it can multiply in our body and cause the creation of antibodies. The designers got it wrong:

• Protein S spreads and stays longer than expected in the body.
• It is dangerous and causes a form of covid.
• The effects were not studied because carried out on wild mice which underestimate the ACE2 of the man, they were not visible.
• The recent effects carried out on transgenic mice capable of reproducing what happens in humans highlight the disastrous effects.

To date, not the slightest study on the risks of the said injected protein for women of childbearing age, for those who have had covid, for those vaccinated against influenza, for young people …

Your doctor does not worry about vaccination without prior studies, ask him to read these very technical studies, he will understand …

Our data suggest that pro-inflammatory mediators released by spike-activated macrophages enhance endothelial cell activation, possibly contributing to impaired vascular integrity and the development of a pro-coagulant endothelium.

• pubmed.ncbi.nlm.nih.gov/34572407

We conclude that the spike protein alone without the rest of the viral components is sufficient to trigger cell signaling in HPAEC, and that treatment with HbA failed to reverse the vast majority of these changes induced by the spike protein.

• pubmed.ncbi.nlm.nih.gov/34445747

The regulatory role of the SARS-CoV-2 protein spike in infected cells and attempted to elucidate the molecular mechanism of inflammation induced by SARS-CoV-2.

• pubmed.ncbi.nlm.nih.gov/34461258

The S1 subunit of the SARS-CoV-2 spike protein induces acute COVID-19-like lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells.

• t.co/CAeiQC0CFh?amp=1

Here, we demonstrate that intratracheal instillation of a single SARS-CoV-2 element, S1SP, in K18-hACE2 transgenic mice induces local (pulmonary) and systemic COVID-19 inflammatory responses.

• ncbi.nlm.nih.gov/labs/pmc/articles/PMC8384477
• pubmed.ncbi.nlm.nih.gov/34406358

• We finally have results on the consequences of Pfizer on mice and we better understand why they refuse post-injection autopsies for deceased humans.

FINALLY THE FIRST STUDIES ON THE EFFECTS OF SPIKE VACCINE PROTEIN

Few autopsies after post-vaccination death

First histopathologic image of post-vaccine myocarditis in a 65-year-old man who died 11 hours after his second dose of Pfizer mRNA. Massive infiltration of lymphocytes perivascular and between cardiomyocytes Why are the lymphocytes so excited there? The effect of the vaccine spike? By injecting the active principle of the disease, we cause a kind of covid.

• pubmed.ncbi.nlm.nih.gov/34591186

Reports of effects of the spike protein come mostly from dermatologists

Response of T cells with features of interface dermatitis and interstitial granulomatous inflammation.

• sciencedirect.com/S0738081X21001516

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Dr Siang’s terrible warning validated by the first post-autopsy images

Around the world, I see efforts to support ‘quick fix’ programs aimed at developing vaccines and therapies for COVID-19. Groups in the United States and China are already planning to test vaccines on healthy human volunteers. Make no mistake, it is essential that we work as hard and as fast as possible to develop drugs and vaccines that are widely available around the world. But it’s important not to cut corners.

Measles, mumps, rubella, polio, smallpox, and influenza vaccines have a long history of safe use and have been developed in accordance with the requirements of regulatory agencies.

I have been working on the development of coronavirus vaccines and treatments since 2003, when the Severe Acute Respiratory Syndrome (SARS) outbreak occurred. In my opinion, standard protocols are essential to protect health. Before authorizing the use of a COVID-19 vaccine in humans, regulators must assess safety with a range of viral strains and in more than one animal model. They should also demand strong preclinical evidence that investigational vaccines prevent infection, although this will likely involve waiting weeks, or even months, for models to become available.

It is time well spent. Work with the SARS virus shows disturbing immune responses have been observed in ferrets and monkeys, but not in mice. Additionally, certain fragments of viral proteins may elicit stronger or less risky immune responses than others, and it makes sense to learn this in animal studies before trying them in humans.

Decades ago, vaccines developed against another coronavirus, the feline infectious peritonitis virus, increased cats’ risk of developing the disease caused by the virus (T. Takano et al. J. Vet. Med. Sci. 81, 911-915; 2019). Similar phenomena have been seen in animal studies for other viruses, including the coronavirus that causes SARS (YW Kam et al. Vaccine 25, 729-740; 2007).

Regulators must continue to require vaccine developers to check for potentially dangerous responses in animal studies. They should also make sure to assess healthy human volunteers for antibodies to coronaviruses before enrolling them in safety trials. Donors must beware of the hype and release more grants for appropriate testing for the development of coronavirus drugs and vaccines.

My concern is that this could mean that a vaccine is given before its efficacy and safety has been fully evaluated in animal models or clinical trials.

Another factor must also be taken into account: the potential of emerging and re-emerging coronaviruses to cause future epidemics. The virus behind COVID-19 may well mutate in a way that would render previously effective vaccines and antivirals unnecessary. Therefore, any regulatory body considering ways to speed up treatments in testing should also weigh the likelihood that these drugs will work beyond this particular coronavirus.

Testing vaccines and drugs without taking the time to fully understand the safety risks could lead to unwarranted setbacks during the current pandemic and into the future. The public’s willingness to support quarantines and other public health measures to slow the spread tends to correlate with people’s trust in government health advice. A rush for potentially risky vaccines and therapies will betray that trust and discourage work to develop better evaluations. Despite the real need for urgency, the old adage holds: measure twice, cut once.

Nature 579, 321 (2020)

Around the world, I see efforts to support ‘quick fix’ programs to develop vaccines and therapies for COVID-19. Groups in the United States and China are already planning to test vaccines on healthy human volunteers. Make no mistake, it is essential that we work as hard and as fast as possible to develop drugs and vaccines that are widely available around the world. But it’s important not to cut corners. doi: https://doi.org/10.1038/d41586-020-00751-9

Measles, mumps, rubella, polio, smallpox, and influenza vaccines have a long history of safe use and have been developed in accordance with the requirements of regulatory agencies.

Shibo Jiang

Shibo Jiang is Professor of Virology at the School of Basic Medical Sciences, Fudan University, Shanghai, China, and at the New York Blood Center, New York, USA.

• sciencedirect.com/S0738081X21001516

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• ” France has openly violated the precautionary principle for young women “
• ” The high health authority launches the influenza covid vaccination but there are no studies on the issue yet “

source: https://pgibertie.com