The psychotic episode is related to a high risk of liver disease – News Archives – iSanidad

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People who have suffered a first psychotic episode are at high risk of developing short-term liver disease. In fact, 21.9% develop fatty liver within the first three years from the onset of their first psychotic episode. This is indicated by a collaborative study led by researchers from the Cyber ​​Mental Health area (Cibersam) at the Virgen del Rocío Hospital in Seville – Seville Institute of Biomedicine (IBIS); and from the Ciber Hepatic and Digestive Diseases area (Ciberehd) at the Marqués de Valdecilla Hospital – Valdecilla Health Research Institute (Idival) The results, published in the journal Schizophrenia Research, indicate that these patients have a higher risk of presenting increased weight “and metabolic alterations such as diabetes, dyslipidemia, or metabolic syndrome”, explains Javier Vázquez Bourgon, Cibersam researcher and one of the coordinators of this work. Javier Vázquez: “The objective of this study was to see if patients with psychosis also present liver involvement more frequently” In the general population, it is known that these metabolic alterations are closely associated with the appearance of fatty liver. This can evolve into more serious and chronic forms of liver disease. “Given that patients with psychosis have a higher risk of presenting weight gain and metabolic alterations, the objective of this study was to see if they also present this liver involvement more frequently,” says the researcher. Changes at the metabolic and hepatic level
For this, data from 160 people who had suffered a first episode of psychosis were analyzed, comparing them with 66 individuals without mental pathology. In these patients, metabolic and hepatic changes were evaluated over three years, through the fatty liver index (FLI). “The study found that, within the first three years from the onset of their first psychotic episode, up to a fifth of the patients (21.9%) developed fatty liver,” explains Javier Crespo, head of the Ciberehd group at the Hospital Marques de Valdecilla – Idival. In contrast, only 3% of the individuals without psychosis belonging to the control group presented hepatic steatosis in that period. Within the first three years from the onset of their first psychotic episode, up to a fifth of the patients developed fatty liver “In addition, the presence of fatty liver was associated with a worse evolution in metabolic parameters; and with the appearance of Metabolic Syndrome and high blood pressure in patients with this mental health disorder”, adds the researcher. Thanks to this research there is more evidence of the association between psychosis and liver involvement. This “emphasizes the importance of including in routine practice actions aimed at the early detection of metabolic pathology as well as liver pathology in patients with a first episode of psychosis,” says Benedicto Crespo, head of the Cibersam group at the Hospital Virgen del Rocío and IBIS. “All these data represent an advance in the knowledge of the metabolic impact at the hepatic level in patients with psychosis”, the researchers conclude. Complementary news