The genes of people who reach 100 years are inherited. The descendants of people who reach 100 years of life are less fragile, have better health, than the descendants of people who have not reached this advanced age. This has been revealed by a study, which has carried out a genetic analysis of descendants of centenarians, which indicates that these people inherit a specific genetic footprint that may explain why they have fewer age-related pathologies. The genetic footprint of 100 years This study published in ‘The Journals of Gerontology’ and led by a team from the area of Frailty and Healthy Aging of the CIBER (CIBERFES), the Health Research Institute (INCLIVA) and the University of Valencia (UV), has studied the functional and genetic profiles of descendants of centenarians and non-centenarians of the same age. The starting point of this work has been the consideration that centenarians have extreme longevity, a compression of morbidity and a unique genetic signature and their offspring dence appears to inherit compression of morbidity, as measured by lower rates of age-related pathology. The Mediterranean diet prevents cellular aging Bearing this in mind, the objective of this work by the team of José Viña, head of the CIBERFES group, principal investigator of the Research Group on Aging and Physical Exercise at INCLIVA and Professor of Physiology at the Faculty of Medicine of the University of Valencia, was to determine if the offspring of people who reach 100 years of age is less fragile and if there is a centenarian genetic fingerprint. descendants of these and 88 descendants of people who are not centenarians from a health area near Valencia. The people who were part of the study had to meet a series of conditions: having a parent alive who was over 97 years old, being between 65 and 80 years old and not suffering from any terminal illness. In addition, frailty status was determined according to the 5 criteria of the Linda Fried phenotype, whereby a person with unintentional weight loss, exhaustion, muscle weakness determined by weak grip strength, slow walking speed, and low physical activity is considered frail. Genes for reaching 100 are inherited “Our results show that the descendants of centenarians have a lower prevalence of frailty in relation to their contemporary descendants of non-centenarians”, explains Consuelo Borrás, study coordinator, CIBERFES researcher and Principal Investigator of the Healthy Aging Research Group of INCLUDED. They design a drug to destroy old cells and slow down aging Likewise, the researchers collected plasma and peripheral blood mononuclear cells from the individuals in the sample. They found that the gene expression patterns (miRNA and mRNA) of the descendants of the centenarians were more similar to those of the centenarians than to those of the non-descendants, despite having the same age. Therefore, as Consuelo Borrás indicates, offspring of centenarians are less frail than offspring of non-centenarians of the same age, “which may be explained by their unique genetic endowment.” centenarians and non-centenarians, reinforces the idea that the former are genetically distinct from their contemporaries and resemble the unique genetic characteristics of centenarians.”Therefore, our results may contribute to advancing the identification of key genetic and functional characteristics that can be considered biomarkers of successful aging”, explains José Viña.People who reach 100 years old age wellThe hope of living has increased remarkably in the last century. In fact, according to studies, in Spain, it has increased by 40 years between 1910 and 2009. The proportion of people over 60 years of age is growing faster than any other age group, due to both this increase in longevity and the decrease of fertility rates. They discover why exercise protects against aging Much of the research in this area has focused on increasing the number of years spent without disabilities, which is called ‘successful aging’. Centenarians are considered model cases of this successful aging , since they seem to prevent or greatly delay the onset of age-related diseases or geriatric syndromes, so these people show a slowed aging trajectory.
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