NewsWorldCompleted the genomic map of chronic lymphatic leukemia -...

Completed the genomic map of chronic lymphatic leukemia – Diario de León

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An international team of researchers, with the participation of Spanish scientists, has completed the map of the genetic changes in chronic lymphatic leukemia (CLL), the most common in the Western world. This tool will provide a better understanding of the disease and may lead to more accurate prognoses for patients, improved diagnoses and the development of new treatments. The study, published yesterday in the journal Nature Genetics, has analyzed the genome of more than 1,000 patients, and has been coordinated by researchers from the IDIBAPS-Hospital Clínic, the University of Barcelona, ​​​​the University of Oviedo, the Cancer Network Biomedical Research Center (Ciberonc), the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard University (United States), and the University of Ulm (Germany). Chronic lymphatic leukemia (CLL) is a type of blood cancer and is the most common type of leukemia in the Western world, with an incidence around 5 cases per 100,000 inhabitants and year. It is characterized by an increase in the number of B lymphocytes, a type of white blood cell, which can be detected accidentally in a routine analysis. In some cases it can have a slow growth and a good prognosis, while in others it can be fast and aggressive. Knowledge of the molecular alterations that cause this very different evolution could allow knowing the prognosis at an early stage. Previous studies had provided fragments of a map of CLL, each focused on particular types of patients or with limited data. “The goal of this study has been to provide a virtually complete catalog of all genomic alterations that cause CLL and its molecular subtypes. It has been an immense effort by a large international team that has analyzed the genome of more than 1,000 patients using new bioinformatic tools for more than 4 years”, remarked the co-lead author of the study and head of the Molecular Pathology of Lymphoid Neoplasms group at the IDIBAPS, Elias Campo.

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