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Covid: Here’s why more and more vaccinees will be infected with the 7th wave of BA.4 and BA.5 – The Independent

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Recent studies have determined the level of immune escape of emerging variants. It is extraordinarily higher than the original strain of Omicron. As summer approaches, the new wave of Covid-19 is inevitable… The 7th has already started in France and for specialists, there are no surprises. If, for the moment, the wave carried by the BA.2.12.1, BA.4 and BA.5 variants does not seem particularly virulent, it should contaminate a very large part of the population, vaccinated or not. Already infected or not. There are several explanations for this. First of all, the level of antibodies of vaccinated people has dropped considerably, the recall campaign dating back several months. However, it has been demonstrated that the level of antibodies drops sharply a few weeks after the injection. Vaccinated and infected with little protection In addition, the vaccines, which were already less effective on Omicron than on the original strain of the Sras-CoV-2 virus, are even less effective on the new variants. Recent studies have thus demonstrated that the BA.2.12.1, BA.4 and BA.5 variants have a much greater immune escape than the previous versions. That is to say, they more easily escape the protection of natural antibodies acquired by infection, such as those provided by vaccines. It will therefore not be surprising to see, in this wave carried by the BA.2.12.1, BA.4 and BA.5 sub-variants, increasingly infected vaccinated people. Persons already infected (vaccinated or not) are no longer immune to reinfection. What hope? These studies demonstrate that with each mutation, Sras-CoV-2 evolves ever more towards an increase in neutralization escape. A priori, it will therefore be impossible to escape this BA.2.12.1, BA.4 and BA.5 wave, which was not, however, accompanied by increased danger during its passage through South Africa. Ultimately, the only hope of countering the spread of the virus lies in the effectiveness of future updates to Messenger RNA vaccines. Moderna thus announced, on Wednesday, very positive results from the second version of its vaccine on BA.4 and BA.5. Currently under study on a European scale for marketing before the fall, this vaccine will not be released before the end of the 7th wave. Hoping that it will be just as effective on the sub-variants of BA.4 and BA.5 which will surely emerge in the coming months. One month after administration in previously vaccinated and boosted participants, a 50 µg #booster dose of mRNA-1273.214 elicited potent neutralizing antibody responses against the #Omicron subvariants BA.4 and BA.5 in all participants regardless of prior infection. pic.twitter.com/t6BQTrgCoO— Moderna (@moderna_tx) June 22, 2022 In the meantime, the most fragile are invited to be vaccinated with the available vaccines which, if they are not particularly effective on the spread of the virus, remain the best ramparts against serious forms of the disease.

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