https://fr.sputniknews.com/20220127/a-une-mutation-near-wuhan-researchers-keep-an-eye-the-neocov-another-coronavirus-1054629929.html
With one mutation: Wuhan researchers keep an eye on NeoCoV, another coronavirus
With one mutation: Wuhan researchers keep an eye on NeoCoV, another coronavirus
Close to MERS-CoV 2, the NeoCov coronavirus identified in bats in South Africa has a receptor capable of mutating to infiltrate… 27.01.2022, Sputnik France
2022-01-27T15:01+0100
2022-01-27T15:01+0100
2022-01-27T16:18+0100
South Africa
researchers
virus
vaccine
study
middle east respiratory syndrome coronavirus (seas)
bats
wuhan
COVID-19
coronavirus sars-cov-2
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Chinese scientists warn of the potential threat of a coronavirus discovered in South Africa in animals, capable of infecting humans and causing a fatal and transmissible disease. This coronavirus called NeoCov, which spreads among bats, has been studied for at least 10 years. According to this new study prepublished on the bioRxiv site, the virus has an enzyme of the same type as that of SARS-CoV-2, in particular the ACE2 receptor, which allows it to enter the lungs. However, the enzyme specific to NeoCov acts only in animals. The researchers warn that a single mutation in its genome would be enough for the virus to acquire the ability to infiltrate human cells. In addition, the NeoCov is genetically close of another coronavirus, MERS-CoV, which caused the deadly epidemics that occurred in the Middle East in 2012 and 2015. Its mortality reached 35% of diagnosed cases. At least 85% of the NeoCov genome is identical to MERS-CoV 2 at the nucleotide level, underlines a study published in 2014 in the Journal of Virology, and carried out by German and African researchers. As a result, the risk of mortality from an infection caused by NeoCov is estimated to be high. Finally, the potential danger of the new coronavirus is associated with its escape from antibodies due to the particular characteristics of the ACE2 receptor, suggest the researchers of the Wuhan University and the Institute of Biophysics of the Chinese Academy of Sciences. In other words, neither the immunity achieved thanks to the antibodies formed during the disease nor that obtained by vaccination could provide effective protection. This coronavirus had was mentioned in a study conducted by an international group of researchers, published in 2020 in the American journal Infectious Diseases: Research and Treatment, on the similarities and differences between NeoCov, MERS-CoV and SARS-CoV, responsible for the epidemic of severe acute respiratory syndrome which raged from 2002 to 2004. According to scientists, this new betacoronavirus was baptized NeoCov in 2011.Risk assessmentC Commenting on the potential dangers presented by the Chinese researchers, their Russian colleagues highlighted several elements. Questioned by Sputnik, the National Center for Research in Virology and Biotechnology Vektor, which developed the second Russian vaccine against Covid-19, EpiVacCorona, notes that this virus is currently unable to spread to the human population. It also underlines the need for more in-depth studies. However, it is impossible to predict with certainty in which direction the new coronavirus could mutate, adds a virologist from the Gamaleïa Research Center for Epidemiology and Microbiology, designer of Sputnik V. We sometimes manage to obtain from strains from nature, variants that cause a good immune response and remain harmless for humans. As an example, he cites a yellow fever vaccine whose immunity lasts 10 to 20 years after a single injection.
South Africa
wuhan
2022
Anastasia Patts
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Anastasia Patts
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Anastasia Patts
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bats, middle east respiratory syndrome coronavirus (seas) coronavirus, covid-19, coronavirus sars-cov-2, sputnik v, center for epidemiology and russian microbiology gamaleïa
Close to MERS-CoV 2, the NeoCov coronavirus identified in bats in South Africa has a receptor capable of mutating to infiltrate human cells and escape antibodies, indicates a study by Chinese researchers. Russian virologists point to the impossibility of predicting a path of transformation.
Chinese scientists warn of the potential threat of a coronavirus discovered in South Africa in animals, capable of infecting humans and causing a deadly and transmissible disease.
The researchers warn that a single mutation in its genome would be enough for the virus to acquire the ability to infiltrate human cells.
In addition, NeoCov is genetically close to another coronavirus, MERS-CoV, which caused the deadly epidemics that occurred in the Middle East in 2012 and 2015. Its mortality reached 35% of diagnosed cases.
Finally, the potential danger of the new coronavirus is associated with its evasion of antibodies due to the particular characteristics of the ACE2 receptor, suggest the researchers from Wuhan University and the Institute of Biophysics of the Chinese Academy of Sciences.
Risk Assessment
Commenting on the potential dangers presented by the Chinese researchers, their Russian colleagues highlighted several elements. Questioned by Sputnik, the National Center for Research in Virology and Biotechnology Vektor, which developed the second Russian vaccine against Covid-19, EpiVacCorona, notes that this virus is currently unable to spread to the human population. It also highlights the need for more in-depth studies.
“Mutations can not only lead to the strengthening of the pathogenic power of the virus, but also to reduce it”, advances Alexandre Boutenko to Sputnik Radio.
“We sometimes manage to obtain from strains from nature, variants which cause a good immune response and remain harmless for humans”. As an example, he cites a yellow fever vaccine whose immunity lasts 10 to 20 years after a single injection.
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