Vaccine and variants, third dose increases protection up to 44 times

The efficacy of the vaccine increases with the third dose and the protection against variants increases by up to 44 times with the booster. While Italy begins the administration of the third dose of the anti-Covid vaccine to the first selected groups of the population, its usefulness, at least for the elderly and frail, does not seem to be questioned by the data presented by the immunologist and scientific advisor of the White House. Anthony Fauci. The expert, at the Florence Congress of Fadoi hospital internists, in relation to the main variants of Sars-CoV-2 speaks of an increase in the shield effect “up to 44 times” after the recall. “15 days after the administration of the third dose of Moderna – he said, according to a note from the Federation of associations of internist hospital managers – compared to more variants we can see a 23-fold increase in protection” against “the D614G mutation ( the first relevant compared to the original Wuhan strain, ed), 32 times compared to the B.1.351 mutation “, called ‘South African’ and” finally 44 times compared to the P.1 mutation “, called ‘Brazilian’. “Data similar to those detected for the Pfizer booster and indiscriminately in young and old, in which there were drastic increases in antibody levels and protection in relation to severe forms of disease and infections”, explained Fauci who received from the Italian internists the ‘Internal Medicine Research Award 2021’ and upon delivery expressed “respect and gratitude to Fadoi doctors for their dedication to patients during the pandemic and their simply fantastic expertise.” especially in light of the impact of the Delta variant of Sars-CoV-2, whose transmissibility “is much more efficient than the other variants and the viral load in the upper airways of infected people is up to a thousand times higher than other variants such as the Alpha. In the United States this has resulted in a decline in the effectiveness of vaccines against severe forms of the disease resulting in hospitalizations, which is from 91 to 81% for Moderna and from 85 to 75% for Pfizer “. As for the third dose, it is also on the basis of the numbers cited by Fauci that, as recalled by the immunologist himself, the American FDA recently authorized the booster dose of the Pfizer vaccine for people aged 65 and over and for those aged 18 years and older with a high risk of developing a severe form of Covid-19 infection, or even for people at risk. Fauci also wanted to reassure “people who are sometimes worried that only 11 months have passed since the sequencing of the vaccine. virus at the time of the first administrations “. “The speed and efficiency with which these vaccines capable of saving millions of lives have been developed – he explained – are actually due to an extraordinary multidisciplinary effort, which involved basic preclinical and clinical science, carried out. out of the spotlight for decades, before the Covid-19 pandemic “.

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