They break through the vaccine shield and therefore call them ‘breakthrough’ infections. These are the infections that occur between vaccinated people. With the rise of covid variants, especially the Delta, these data are constantly in the spotlight and are monitored closely for signs of failure in prophylaxis. A US study not yet published, and therefore not subject to peer review, but available in a preprint version on the ‘Medrxiv’ platform, compares the effectiveness of the two mRna vaccines, Moderna and Pfizer / BioNTech. The analysis was conducted on data from the Mayo Clinic Health System from January to July 2021, a period in which both the Alpha and Delta variants were widespread, and shows that the effectiveness against infection seems to have decreased less for Moderna. “We defined cohorts of vaccinated and unvaccinated Minnesota people (25,589 people for each of the two groups), matched for age, sex, ethnicity, history of prior Sars-CoV-2 testing and date of complete vaccination,” the authors explain. report the results of their analysis on several fronts. “Both vaccines were highly effective during this study period against Sars-CoV-2 infection and Covid hospitalization. In July, however, if efficacy against hospitalization remained high, efficacy against hospitalization remained high. infection was lower for both shield products (Moderna 76%, Pfizer 42%), with a more pronounced reduction for Pfizer vaccine. This decrease occurred while in Minnesota the prevalence of the Delta variant increased from 0.7 % in May to over 70% in July, and the prevalence of Alpha dropped from 85% to 13% over the same time period. Wisconsin, Arizona, Florida and Iowa), the Moderna vaccine showed a two-fold reduction in the risk of breakthrough infections compared to Pfizer. In Florida, which was experiencing its biggest wave of Covid in July, the risk of infection after vaccination complete was inferior about 60% with Moderna compared to Pfizer. The observational study, it should be noted, highlights that both mRna vaccines strongly protect against infections and serious diseases, but justifies a further evaluation of the mechanisms underlying the differences in their effectiveness, the authors conclude.
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