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Smallpox of monkeys, complete genome sequenced at San Matteo di Pavia

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The team of virologists and researchers of the Irccs Policlinico San Matteo di Pavia Foundation, led by Professor Fausto Baldanti, sequenced the entire genome of a monkeypox virus (Mpvx) strain from the skin vesicle swab of one of the patients returning from Canary Islands. The complete monkeypox genome was sequenced directly from the biological sample using a metagenomics approach with next generation sequencing (Ngs). “A preliminary phylogenetic analysis clearly shows that the obtained genome belongs to the West African clade of Mpxv and is more closely correlated with the strains recently found in Portugal and the rest of Europe – comments Fausto Baldanti, Uoc Microbiology and Virology Director of the San Matteo – Currently, the positive cases diagnosed so far at San Matteo are 4, and the sequencing of the remaining 3 cases is underway. Finally, analyzes are underway for two further suspected cases “. The virologists and researchers who sequenced the genome are Piera D’Angelo, Guglielmo Ferrari, Stefano Gaiarsa, Federica Giardina, Stefania Paolucci, Antonio Piralla, Greta Petazzoni and Federica Zavaglio. “Congratulations to the team of researchers led by Professor Fausto Baldanti – commented the vice president and councilor for Welfare of the Lombardy Region, Letizia Moratti – An important result that certifies the very high international level achieved by biomedical research in Lombard health”.

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