AstraZeneca second dose, Minelli: “Mix vaccines only if low antibodies”

“Before administering a possible second dose of” Covid-19 “vaccine other than that inoculated with the first injection, we check the acquired level of antibody protection. Because, with satisfactory results, there may not be any need to resort to a mix of different vaccines not only in composition, but also in the method of intervention “. This was underlined to Adnkronos Salute by Mauro Minelli, responsible for the South of the Italian Foundation for Personalized Medicine. “If anything – he continues – always monitoring the progress of the post-vaccination immune response over time, we will decide to administer the second dose of vaccine, at that point necessarily different from the first, when the protective antibody load induced by the first is reduced. and single administration. This will avoid unprecedented mixtures, because in the meantime the stimulating action on the immune system of the first administered vaccine will be exhausted “. “It may not be necessary – suggests the immunologist – for many of the people who have recently been vaccinated with the AstraZeneca product, to undergo a second administration if, in the meantime, they have developed the fateful Sars-CoV-blocking antibodies. 2 “. According to Minelli,” there is a rationale behind this reasoning. AstraZeneca was born as a single-dose vaccine; it was then found that, in a fair number of people, a single administration could not be sufficient to adequately immunize the vaccine and then that product was reset with double administration, potentially able to provide more satisfactory overall results in terms of immunization “.