Vaccine AstraZeneca to young people in Italy? “Reflection is needed” considering the side effects and the changed epidemic picture. The words of Professor Franco Locatelli, coordinator of the CTS, could open a new page in the ‘leaflet’ of the vaccine, which returned to the spotlight after a case of thrombosis that occurred in an 18-year-old girl who had previously received the first dose of the drug. In Italy, as is known, the AstraZeneca vaccine is recommended for people over 60: in recent weeks, the increasingly frequent ‘open days’ have brought younger groups closer to the vaccine. Anyone who has received the first dose of AstraZeneca is intended to receive the second dose of the same drug. But what does the leaflet say? What are the side effects? The package leaflet was updated following the rare thrombosis cases in Europe. In the leaflet on the Aifa website (here the Pfd), which indicates 18 years as the minimum age limit for administration, the paragraph ‘Blood disorders’ reads: “Very rare blood clots, often in unusual sites (eg eg brain, intestine, liver, spleen), in association with low levels of blood platelets, in some cases accompanied by bleeding, have been observed after vaccination with Vaxzevria. This condition included severe cases with blood clots at different sites or as well as excessive clotting or bleeding throughout the body. Most of these cases occurred within the first fourteen days after vaccination and mainly occurred in women under 60 years of age. In some cases this condition resulted in death “. The section on ‘Possible side effects’ also reads:” Like all medicines, this vaccine can cause side effects, although not everybody gets them. If you notice any side effects not mentioned in this leaflet, please tell your doctor, pharmacist or nurse. Get urgent medical attention if symptoms of a severe allergic reaction occur. These reactions may include a combination of any of the following symptoms: – feeling faint or lightheaded – changes in heartbeat – shortness of breath – wheezing – swelling of the lips, face or throat – hives or rash – nausea or vomiting – stomach pain The following side effects may occur with Vaxzevria: Very common (may affect more than 1 in 10 people) – tenderness, pain, warmth, itching or bruising where the injection is given – feeling tired (fatigue) ) or feeling generally unwell – chills or feeling feverish – headache – feeling sick (nausea) – joint pain or muscle pain Common (may affect up to 1 in 10 people) – swelling or redness where it is used injection – fever (> 38 ° C) – being sick (vomiting) or diarrhea – low blood platelet levels Uncommon (may affect up to 1 in 100 people) – sleepiness or feeling dizzy – decreased appetite – swollen lymph nodes – excessive sweating, itching or rash Very rare (may affect up to 1 in 10,000 people) – blood clots often in unusual sites (eg. brain, intestine, liver, spleen), associated with low levels of platelets in the blood “.