“We must take away the virus, not let it run. If we reduce the pool of people who can be affected, we will also reduce the development of new variants” of Sars-CoV-2. It is one of the reasons why Sergio Abrignani, immunologist at the University of Milan, among the experts of the Technical Scientific Committee for the coronavirus emergency, in an interview with the ‘Corriere della Sera’ launches an appeal to adolescents and their parents: “Make a great gesture in the interest of the community”, adhering to the anti-Covid vaccination without fear and with conviction. “In Italy we have cried 126 thousand dead – he recalls – The lives of all of us have been turned upside down. The children have suffered a lot, deprived of their freedoms, and will understand that now they must participate in the reconstruction of normality”. “The health authorities of countries that have already vaccinated millions of young people between 17 and 25 years of age, such as Israel and the United States – explains Abrignani – have reaffirmed that the protection of young people, therefore also of adolescents, is of primary importance in ‘scope of a virus containment strategy “. Because if it is true that “adolescents are not victims of Covid and hardly have severe forms of the disease”, in any case “they are infected and in turn infect. If they were not vaccinated, the virus would circulate more, creating public health problems”. after having secured 50 million Italians with one or two doses “of vaccine, the specialist points out,” about 1% of them will not be exempt from the risk. Cancer patients undergoing chemotherapy or autoimmune patients with a very strong immune system compromised by immunosuppressive therapies, they do not respond to vaccination and therefore could be infected and have very serious consequences, even fatal. For this reason I strongly hope, and I believe, that the very young will not hold back not feeling personally in danger “. Also because with the variants of the pandemic coronavirus “so far we have gone well – observes Abrignani – Those that have presented themselves, including the so-called Indian indicated by the WHO as the Delta variant, have not greatly affected the effectiveness of the vaccines. But if we give the Sars-CoV-2 other opportunities to replicate – he warns – in the end he could guess the mutation capable of escaping prophylaxis “. The 20-year-olds are responding well to the call. Might not the same happen with the little ones? “No, I’m confident – says the CTS immunologist – I feel a favorable climate. There is a desire to take back the lost space. They will go back to school free again. Don’t be afraid, vaccines are effective and safe”. General Figliuolo believes that herd immunity can be achieved in September. Abrignani agrees, or does he think like his colleague Anthony Fauci that herd immunity is an unattainable goal? “The emergency commissioner has done an incredible job. Today, however, it is difficult to estimate if and when we will reach herd immunity – he warns – because we do not know to what extent the vaccinated, although sheltered from the disease, are not contagious. . It is not known exactly how many are protected from asymptomatic infection. On the one hand, as an immunologist, I share Fauci’s uncertainty, on the other hand I think it is very important to set goals and imagine that in September we could achieve group immunity “. In the meantime, when will we equal Britain which has been stuck on 1-2 victims a day for Covid-19 for weeks? “I hope by the end of June – estimates the expert – To go down to these levels, however, we will have to vaccinate most of the susceptible to the serious effects of the virus and about 2.5 million over-sixties are still missing”. Finally, clarity on the serological tests referred to. there is great demand. For Abrignani “it doesn’t make much sense to do a serological test to measure antibodies. There is no correlation of protection against infection, that is, we do not know what the level above which there is protection is. Furthermore, there are no standardized tests, but many different tests. In medicine there are no diagnostic tests whose response does not lead to decisions or to inform about the clinical course “. The serological ones, rather, “serve to establish at the epidemiological level the percentage of the population that has been infected asymptomatically”.