From the Italian research “an important step forward in the new frontier of the fight against cancer that exploits the immune system”, that of anticancer vaccines. Scientists from the Armenise-Harvard immunoregulation laboratory of the Igm (Italian Institute for Genomic Medicine), based at Irccs Fpo in Candiolo, Turin, directed by Luigia Pace, have discovered that “it is possible to induce an effective immune response against cancer using an adenoviral vaccine, safe for humans, which codes for mutations present in cancer cells “. The study was published in ‘Science Translational Medicine’, in collaboration with the Swiss-Italian biotech company Nouscom. “Until now – underlines Pace – the mechanism by which adenoviral vaccines instruct the immune system to target cancer cells was not known and also for this reason their efficacy in the treatment of cancer patients was doubtful. With this discovery an important discovery has been made. step forward, so much so that it is reasonable to think that a vaccine therapy based on adenoviral vectors will soon become a concrete therapeutic option in oncology “. The specialist explains that “in vaccines constructed with adenoviral vectors, a high number of tumor mutations can be encoded. In combination with checkpoint inhibitor (anti PD-1) immunotherapy drugs, they have been shown to be effective against the tumors studied”. been studied in the laboratory – reports a note from the Armenise-Harvard Foundation – the new vaccine was also the subject of a first clinical study conducted in the USA by Nouscom, on 12 patients with colon cancer of the Msi type (with instability of the micro satellites) in metastatic phase.In chronic diseases – the note recalls – lymphocytes, cells of our immune system, lose the ability to control both infection and tumor progression. However, a small group of lymphocytes called CD8 +, which have the function of identifying and killing virus-infected cells or cancer cells, retain the ability to activate an effective immune response and kill cancer cells. Researchers from the Iigm immunoregulation laboratory observed that the vaccine increases the number of CD8 + lymphocytes both in the lymph nodes and in the tumor: “A fact that opens up new perspectives in precision medicine for the treatment of tumors resistant to immunotherapy and at risk of relapse” , says Pace. “We have understood – he highlights – what is the mechanism of action that determines the effectiveness of the vaccine”, and “thanks to this increased knowledge we can transform our experimental analyzes into more precise targeted therapies for each patient”. “Furthermore, considering that the technique for making these vaccines is decidedly tested (the vaccine platform works like that of other vaccines, including preventive infectious diseases, already available on the market), and that the data obtained in the first clinical trial are very promising – concludes the expert – there is a real possibility of creating new vaccines effective against many other types of cancer “.
1 thought on ““Effective and safe anticancer vaccine”, Italians reveal mechanism”
Comments are closed.
Download Tegan and Sara – Love You to Death Album Mp3 Zip 2016-06-03
Download Medrado – Fatos Sobre Mim Album Mp3 Zip 2016-06-03
Download Jorn – Heavy Rock Radio Album Mp3 Zip 2016-06-03
Download The Traveling Wilburys – The Traveling Wilburys Collection (Deluxe Edition / Remastered 2016) Album Mp3 Zip 2016-06-03
Download Brennan Heart – I Am Hardstyle Album Mp3 Zip 2016-06-03
Download Mato – Hollywoo Dub Album Mp3 Zip 2016-06-03
Download Hellyeah – Unden!able Album Mp3 Zip 2016-06-03
Download Various Artists – Now That’s What I Call Rock Ballads Album Mp3 Zip 2016-06-03
Download Moonface & Siinai – My Best Human Face Album Mp3 Zip 2016-06-03
Download Totgeglaubt – Neubeginn Album Mp3 Zip 2016-06-03
Download The Vision Bleak – Timeline – An Introduction to the Vision Bleak Album Mp3 Zip 2016-06-03
Download Alle Farben – Music Is My Best Friend Album Mp3 Zip 2016-06-03
Download Neonschwarz – Metropolis (Remixes) Album Mp3 Zip 2016-06-03
Download Faces on TV – Traveling Blind – EP Album Mp3 Zip 2016-06-03
Download Navii – Tout se donner Album Mp3 Zip 2016-06-03
Download Hedvig Mollestad Trio – Black Stabat Mater Album Mp3 Zip 2016-06-03
Download The Sisterhood – The Sisterhood (Alyssa Bonagura & Ruby Stewart) – EP Album Mp3 Zip 2016-06-03
Download Paradox – Pangea Album Mp3 Zip 2016-06-03
Download The Lonely Island – Popstar: Never Stop Never Stopping (Original Soundtrack) Album Mp3 Zip 2016-06-03
Download Troglauer Buam – Ey-Oh! Album Mp3 Zip 2016-06-03
Download Jenny Weisgerber – Ashes to Stardust Album Mp3 Zip 2016-06-03
Download Brad Mehldau Trio – Blues and Ballads Album Mp3 Zip 2016-06-03
Download ALA.NI – You & I Album Mp3 Zip 2016-06-03
Download Bad Habits – Hell on Wheels – EP Album Mp3 Zip 2016-06-03
Download Virus – Memento Collider Album Mp3 Zip 2016-06-03