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Gasbarrini (Gemelli): “Microbiota is an extraordinary resource for the organism”

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“The intestinal microbiota, a real new organ within the digestive system, not only controls the immune system and metabolism but defends us from pathogens and is even capable of producing or controlling the production of neurotransmitters that are capable of affect neuropsychiatric or neurodegenerative pathologies such as Alzheimer’s. We are talking about an extraordinary resource, fundamental for the body which, however, must be controlled “. Thus Antonio Gasbarrini, director of the Digestive System Disease Center of the Gemelli Irccs University Polyclinic Foundation in Rome, on the sidelines of the event” Not only Covid: tell the Microbiota, between research, innovation, medicine and infodemic “, which took place in Rome today with the non-conditioning support of Alfasigma.” What happens when the microbiota in equilibrium becomes dysbiotic? What happens when bacteria from the colon migrate to the small intestine or the barrier is altered with bacteria entering the body? It happens that various diseases can develop, some of them extremely serious. So it is essential to control this resource that our body has ”, reiterates Gasbarrini. But how can a dysbiotic microbiota be modulated? “Certainly with the diet – he replies – with probiotics and prebiotics, but we must be careful because the knowledge we have of this complex organ is still limited. It can be rebalanced with microbiota transplantation, an extraordinary technique currently limited to antibiotic-resistant bacterial diseases, and with antibiotics. Some antibiotics work by decreasing some pathogenic bacteria while others promote the growth of health promoting bacteria. In this sense, the mechanism of action of rifaximin is interesting, which acts positively on the microbiota in an eubiotic sense “. For Gasbarrini “we are facing a real revolution in progress – adds the expert – which is even telling us that non-communicable diseases, such as ulcerative colitis and depression, are probably transmitted through a microbiota passage from a person to the other “. A mother “with major depression – according to the knowledge we have – can transmit a microbiota that could increase the baby’s risk of developing depression too. This is why we have to work, especially in the first years of our children’s lives, to ensure that they have a microbiota that is as balanced as possible, ”he concludes.

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