Guided missiles, that is, designed to go straight to the tumor with the aim of eliminating it. Not only. They strike through an innovative mechanism, in a sort of game of risk with the disease: first they detect a “bug”, a weak point on the surface of the pathological cell, an unprotected passage, where they slip to release cytotoxins, even 10,000 times more potent than standard chemotherapy, without touching healthy tissue or minimizing damage. It is not a futuristic film, this is how drug-conjugated antibodies work, the last frontier of immunotherapy against multiple myeloma. Belantamab mafodotin, now also available in Italy, is one of these intelligent “weapons”, Gsk explains in a statement. Technically it is a ‘conjugated’ monoclonal antibody, i.e. composed of two molecules: a humanized monoclonal antibody (belantamab) specialized in finding the flaw: a receptor expressed on the surface of myelomatous plasma cells, called Bcma, antigen of maturation of B lymphocytes. at the cell surface, belantamb rapidly enters the plasma cell and ‘releases’ mafodotin, a chemotherapy that blocks the vital processes of the plasma cell, causing its death through a mechanism called ‘apoptosis’. This main action is flanked by others of activation of the patient’s immune system, which enhance the anti-myeloma effect. In clinical studies, and in real life, the drug has been shown to be able to keep myeloma at bay – highlights Gsk – and to increase survival in multi-treated patients, for whom no further therapeutic possibilities exist to date. According to the approval indications, approximately 200 patients can currently benefit from it, of the approximately 5,700 who are diagnosed with myeloma each year. Throughout 2021, pending AIFA’s go-ahead, GSK has made belantamab available free of charge to the centers that have requested it, thanks to an Expanded Access Program project. Treatment with belantamab mafodotin, which involves an intravenous infusion every 3 weeks, in the pivotal clinical study Dreamm-2, published by Lancet Oncology, achieved an overall response rate of 32%. Over half of the patients (58%) achieved a very good or superior partial response and in some cases complete. Median overall survival was approximately 14 months, a surprising result in this particular subpopulation of patients. Belantamab mafoditin is produced and exported all over the world from the Gsk plant in San Polo di Torrile, a stone’s throw from Parma. Production started in 2019 with an investment of 7.5 million euros. Multiple myeloma ranks second among the most frequent hematological cancers after non-Hodgkin’s lymphoma and is responsible for 1-2% of all cancers and 10-15% of hematological cancers. It mainly affects the elderly, with an average age at diagnosis of about 70 years (only 2% of patients are under 40); in addition, it is slightly more common in men. The estimated incidence is around 39,000 new cases each year in Europe. According to the tenth edition of ‘Cancer numbers in Italy’, published in 2020 by the Italian Cancer Registries Association (Airtum), in collaboration with the Italian Association of Medical Oncology (Aiom), reports that in our country every year approximately 5,700 new cases of multiple myeloma, with an incidence of 3,019 cases in men and 2,740 in women. In Italy, multiple myeloma represents 1.5% of all cancers diagnosed in women (7.7 cases per 100,000 inhabitants per year) and 1.6% of all cancers diagnosed in men (11.1 cases per 100,000 inhabitants per year).
1 thought on “Remote guided missile against multiple myeloma, also available in Italy”
Comments are closed.
Download Jinsang – In Flight Album Mp3 Zip
Download Elvis Presley – The Complete ’50s Albums Collection Album Mp3 Zip
Download Sia – Some People Have Real Problems Album Mp3 Zip
Download Loathe – I Let It in and It Took Everything Album Mp3 Zip
Download Tony Bennett & Diana Krall – Love Is Here to Stay Album Mp3 Zip
Download Dropkick Murphys – Turn Up That Dial Album Mp3 Zip
Download Lana Del Rey – Ultraviolence (Deluxe Version) Album Mp3 Zip
Download Anastacia – Ultimate Collection Album Mp3 Zip
Download Various Artists – Chart Hits Pop Playlist 2017/2018 Album Mp3 Zip
Download Logic – Bobby Tarantino II Album Mp3 Zip
Download Força Suprema & Dope Boyz – A Prenda (Vol. 3) Album Mp3 Zip
Download Gunna – WUNNA (Deluxe) Album Mp3 Zip
Download Brooks & Dunn – Reboot Album Mp3 Zip
Download King Krule – Man Alive! Album Mp3 Zip
Download Aimer – Torches – EP Album Mp3 Zip
Download Creedence Clearwater Revival – The Complete Studio Albums Album Mp3 Zip
Download Justin Bieber – Believe (Deluxe Edition) Album Mp3 Zip
Download Killer T – Mashoko Anopfuura Album Mp3 Zip
Download Gaspard Auge & Justice – Escapades Album Mp3 Zip
Download M.I Abaga – Rendezvous Album Mp3 Zip
Download LUNA SEA – Luv Album Mp3 Zip
Download Terror – Total Retaliation Album Mp3 Zip
Download Griselda – Wwcd Album Mp3 Zip
Download EST Gee – I Still Dont Feel Nun Album Mp3 Zip
Download Boney M. – 50 Hits Album Mp3 Zip