A protein rekindles hopes for Parkinson’s disease therapy. It is called Alpha-synuclein and is the protagonist of a study, published in the November issue of the magazine ‘Brain’, the result of the collaboration of a pool of universities, Irccs and Italian research bodies (Università Cattolica campus of Rome, University of Perugia , University of Milan, Cnr of Rome, San Raffaele University Irccs of Rome, University of Rome Tor Vergata and Irccs Santa Lucia Foundation), coordinated by Professor Paolo Calabresi, director of the Uoc of Neurology of the Gemelli Irccs University Polyclinic Foundation and full professor of Neurology of the Catholic University, Rome campus. Researchers investigated the mechanisms by which the abnormal alpha-synuclein protein organizes itself and interferes with the communication between neurons, leading them to irreversible destruction (neurodegeneration). “To study these aspects – explains Calabresi – a very early and progressive animal model of Parkinson’s disease was developed, caused by the activity of alpha-synuclein aggregates and able to reproduce the salient phases of the disease observed in patients” . “We were thus able to identify the mechanisms by which the altered alpha-synuclein determines the first manifestations of the disease. The hope is that this may lead to the discovery of new therapeutic strategies, such as monoclonal antibodies capable of counteracting the spread of the proteins. immunotherapies – underlines the neurologist – would have the purpose of ‘teaching’ the immune system to recognize the abnormal alpha-synuclein early, to destroy it before it causes cell damage “. In short, alpha-synuclein represents “a promising pharmacological target, a new frontier for the search for a therapy (and potentially a cure) for Parkinson’s disease, which is no longer based solely on drugs that relieve symptoms, but on therapies capable of delaying or blocking the progression of the disease “, comments Calabresi. But for the strategy to be successful, early diagnosis is essential. The solution could again revolve around modified alpha-synuclein, which is also at the center of trials for early-phase biomarkers and can be measured in both CSF and blood. “This new biomarker – continues Calabresi – could make it possible in the future to diagnose the disease at an early stage and to intervene with precision medicine strategies. It is therefore not surprising that alpha-synuclein has been dubbed the protein of hope”.
1 thought on “Parkinson’s protein rekindles hopes for therapy”
Comments are closed.
Download Rockapella – Christmas Live Album Mp3 Zip
Download Tyler Ellis – Winter – EP Album Mp3 Zip
Download Banda A Ruiva – Direi Mil Vezes Não – EP Album Mp3 Zip
Download The Tablespoon – Home – EP Album Mp3 Zip
Download Melody NADAL – Un noël jazz – EP Album Mp3 Zip
Download Mar Addai Mar Mari’s Choir – Nishan-D Sawra Album Mp3 Zip
Download Musclu – Riure’s Al Funeral – EP Album Mp3 Zip
Download George Kahumoku, Jr. – Renaissance Man Album Mp3 Zip
Download Herman Berman – The Menorah: It’s Lit Album Mp3 Zip
Download dj flavour – Template Album Mp3 Zip
Download Goa Doc – Progressive Fullon Light 2020, Vol. 2 (Goa Doc 3Hr DJ Mix) Album Mp3 Zip
Download Linda Koolen – Effe Weg Album Mp3 Zip
Download Tara – Résilience Album Mp3 Zip
Download Early Fox – Rich & Poor Album Mp3 Zip
Download Clangsoul – Press Record Album Mp3 Zip
Download Derrin Nauendorf – The World Within Album Mp3 Zip
Download Daridel – Paganroots Album Mp3 Zip
Download Luessy – Omnipotente 2 Album Mp3 Zip
Download Jadiel – El Tsunami Album Mp3 Zip
Download Light User – Light User (feat. Oliver Lewis, Austin Booth & Michael Wall) – EP Album Mp3 Zip
Download No Season – Highwires Album Mp3 Zip
Download Pizzy Moreno & Francisco Proz – Tóxica Hermosura Album Mp3 Zip
Download Kksi – Rouge Album Mp3 Zip
Download Distort – Be Better – EP Album Mp3 Zip
Download Insidious War – Dawn of the Fallen – EP Album Mp3 Zip